CSNK2A1/CK II alpha antibody (N-Term)

Catalog No. ABIN1881717

This anti-CSNK2A1/CK II alpha antibody is a Rabbit Polyclonal antibody detecting CSNK2A1/CK II alpha in WB. Suitable for Human and Rat. This Primary Antibody has been cited in 2+ publications.

Quick Overview for CSNK2A1/CK II alpha antibody (N-Term) (ABIN1881717)

Target: CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSNK2A1/CK II alpha antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CSNK2A1/CK II alpha Antibody

Binding Specificity: AA 28-50, N-Term

Predicted Reactivity: B, C, M, Rb, X, E, D

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Rat Csnk2a1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-50 amino acids from the N-terminal region of Rat Csnk2a1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CSNK2A1/CK II alpha antibody (ABIN1881717)

Li, Li, Müller, Otto, Dietz, von Harsdorf: "Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC." in: Molecular cell, Vol. 10, Issue 2, pp. 247-58, (2002) (PubMed).

Ahmed, Davis, Hanten, Lambert, McIvor, Goueli: "Cloning of cDNAs encoding the alpha and beta subunits of rat casein kinase 2 (CK-2): investigation of molecular regulation of CK-2 by androgens in rat ventral prostate." in: Cellular & molecular biology research, Vol. 39, Issue 5, pp. 451-62, (1994) (PubMed).

Target Details for CSNK2A1/CK II alpha

Target: CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))

Alternative Name: Csnk2a1

Background: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins.

Molecular Weight: 45073

NCBI Accession: NP_446276

UniProt: P19139

Pathways: SARS-CoV-2 Protein Interactome