RAB27A antibody (C-Term)

Catalog No. ABIN1881720

This anti-RAB27A antibody is a Rabbit Polyclonal antibody detecting RAB27A in WB. Suitable for Human. This Primary Antibody has been cited in 5+ publications.

Quick Overview for RAB27A antibody (C-Term) (ABIN1881720)

Target: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB27A antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42745

Product Details anti-RAB27A Antibody

Binding Specificity: AA 136-164, C-Term

Predicted Reactivity: M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RAB27A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the C-terminal region of human RAB27A.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-RAB27A antibody (ABIN1881720)

Ohbayashi, Mamishi, Ishibashi, Maruta, Pourakbari, Tamizifar, Mohammadpour, Fukuda, Parvaneh: "Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2." in: Pigment cell & melanoma research, Vol. 23, Issue 3, pp. 365-74, (2010) (PubMed).

Meeths, Bryceson, Rudd, Zheng, Wood, Ramme, Beutel, Hasle, Heilmann, Hultenby, Ljunggren, Fadeel, Nordenskjöld, Henter: "Clinical presentation of Griscelli syndrome type 2 and spectrum of RAB27A mutations." in: Pediatric blood & cancer, Vol. 54, Issue 4, pp. 563-72, (2010) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Chattopadhyay, Singh, Phukan, Purkayastha, Kataki, Mahanta, Saxena, Kapur: "Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India." in: Mutation research, Vol. 696, Issue 2, pp. 130-8, (2010) (PubMed).

Wood, Meeths, Chiang, Bechensteen, Boelens, Heilmann, Horiuchi, Rosthøj, Rutynowska, Winiarski, Stow, Nordenskjöld, Henter, Ljunggren, Bryceson: "Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity." in: Blood, Vol. 114, Issue 19, pp. 4117-27, (2009) (PubMed).

Target Details for RAB27A

Target: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Alternative Name: RAB27A

Background: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Molecular Weight: 24868

NCBI Accession: NP_004571, NP_899057, NP_899058, NP_899059

UniProt: P51159

Pathways: Peptide Hormone Metabolism