SGOL2 antibody (AA 391-419)

Catalog No. ABIN1881800

The Rabbit Polyclonal anti-SGOL2 antibody has been validated for WB. It is suitable to detect SGOL2 in samples from Human. There are 5+ publications available.

Quick Overview for SGOL2 antibody (AA 391-419) (ABIN1881800)

Target: SGOL2 (Shugoshin-Like 2 (SGOL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGOL2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42663

Product Details anti-SGOL2 Antibody

Binding Specificity: AA 391-419

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SGOL2 antibody (ABIN1881800)

Tanno, Kitajima, Honda, Ando, Ishiguro, Watanabe: "Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres." in: Genes & development, Vol. 24, Issue 19, pp. 2169-79, (2010) (PubMed).

Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

Lee, Kitajima, Tanno, Yoshida, Morita, Miyano, Miyake, Watanabe: "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells." in: Nature cell biology, Vol. 10, Issue 1, pp. 42-52, (2008) (PubMed).

Huang, Feng, Famulski, Rattner, Liu, Kao, Muschel, Chan, Yen: "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments." in: The Journal of cell biology, Vol. 177, Issue 3, pp. 413-24, (2007) (PubMed).

Kitajima, Sakuno, Ishiguro, Iemura, Natsume, Kawashima, Watanabe: "Shugoshin collaborates with protein phosphatase 2A to protect cohesin." in: Nature, Vol. 441, Issue 7089, pp. 46-52, (2006) (PubMed).

Target Details for SGOL2

Target: SGOL2 (Shugoshin-Like 2 (SGOL2))

Alternative Name: SGOL2

Background: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Molecular Weight: 144739

NCBI Accession: NP_001153518, NP_689737

UniProt: Q562F6