ZHX1 antibody (C-Term)

Catalog No. ABIN1882010

The Rabbit Polyclonal anti-ZHX1 antibody has been validated for WB. It is suitable to detect ZHX1 in samples from Human. There are 4+ publications available.

Quick Overview for ZHX1 antibody (C-Term) (ABIN1882010)

Target: ZHX1 (Zinc Fingers and Homeoboxes 1 (ZHX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZHX1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB40545

Product Details anti-ZHX1 Antibody

Binding Specificity: AA 771-800, C-Term

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ZHX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 771-800 amino acids from the C-terminal region of human ZHX1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ZHX1 antibody (ABIN1882010)

Wienk, Lammers, Hotze, Wu, Wechselberger, Owens, Stammers, Stuart, Kaptein, Folkers: "The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension." in: Biochemistry, Vol. 48, Issue 21, pp. 4431-9, (2009) (PubMed).

Kim, Park, Choi, Kim, Park, Jung, Lee, Oh, Im, Bang, Kim: "Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression." in: Biochemical and biophysical research communications, Vol. 355, Issue 2, pp. 318-23, (2007) (PubMed).

Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, (2007) (PubMed).

Liu, Clement, Kanwar, Avila-Casado, Chugh: "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome." in: The Journal of biological chemistry, Vol. 281, Issue 51, pp. 39681-92, (2006) (PubMed).

Target Details for ZHX1

Target: ZHX1 (Zinc Fingers and Homeoboxes 1 (ZHX1))

Alternative Name: ZHX1

Background: The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.

Molecular Weight: 98098

NCBI Accession: NP_001017926, NP_009153

UniProt: Q9UKY1