ZRSR2 antibody (C-Term)

Catalog No. ABIN1882041

This anti-ZRSR2 antibody is a Rabbit Polyclonal antibody detecting ZRSR2 in WB and IHC (p). Suitable for Human. This Primary Antibody has been cited in 4+ publications.

Quick Overview for ZRSR2 antibody (C-Term) (ABIN1882041)

Target: ZRSR2 (Zinc Finger (CCCH Type), RNA-Binding Motif and serine/arginine Rich 2 (ZRSR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZRSR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB44050

Product Details anti-ZRSR2 Antibody

Binding Specificity: AA 453-482, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ZRSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the C-terminal region of human ZRSR2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:25. IHC-P: 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ZRSR2 antibody (ABIN1882041)

Will, Schneider, Hossbach, Urlaub, Rauhut, Elbashir, Tuschl, Lührmann: "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome." in: RNA (New York, N.Y.), Vol. 10, Issue 6, pp. 929-41, (2004) (PubMed).

Scanlan, Gordan, Williamson, Stockert, Bander, Jongeneel, Gure, Jäger, Jäger, Knuth, Chen, Old: "Antigens recognized by autologous antibody in patients with renal-cell carcinoma." in: International journal of cancer. Journal international du cancer, Vol. 83, Issue 4, pp. 456-64, (1999) (PubMed).

Tronchère, Wang, Fu: "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA." in: Nature, Vol. 388, Issue 6640, pp. 397-400, (1997) (PubMed).

Kitagawa, Wang, Hatada, Yamaoka, Nojima, Inazawa, Abe, Mitsuya, Oshimura, Murata: "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1." in: Genomics, Vol. 30, Issue 2, pp. 257-63, (1996) (PubMed).

Target Details for ZRSR2

Target: ZRSR2 (Zinc Finger (CCCH Type), RNA-Binding Motif and serine/arginine Rich 2 (ZRSR2))

Alternative Name: ZRSR2

Background: Pre-mRNA-binding protein required for splicing of both U2-and U12-type introns. Selectively interacts with the 3'-splice site of U2-and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.

Molecular Weight: 58045

NCBI Accession: NP_005080

UniProt: Q15696

Pathways: Ribonucleoprotein Complex Subunit Organization