DNAJB1 antibody

Catalog No. ABIN1882092

This anti-DNAJB1 antibody is a Rabbit Polyclonal antibody detecting DNAJB1 in WB and IHC (p). Suitable for Human and Mouse. This Primary Antibody has been cited in 3+ publications.

Quick Overview for DNAJB1 antibody (ABIN1882092)

Target: DNAJB1 (DnaJ (Hsp40) Homolog, Subfamily B, Member 1 (DNAJB1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1770

Product Details anti-DNAJB1 Antibody

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HSP40 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human HSP40.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:4000. IHC-P: 1:50~100. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-DNAJB1 antibody (ABIN1882092)

Ohtsuka, Hata: "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature." in: Cell stress & chaperones, Vol. 5, Issue 2, pp. 98-112, (2001) (PubMed).

Hata, Ohtsuka: "Characterization of HSE sequences in human Hsp40 gene: structural and promoter analysis." in: Biochimica et biophysica acta, Vol. 1397, Issue 1, pp. 43-55, (1998) (PubMed).

Hata, Okumura, Seto, Ohtsuka: "Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2." in: Genomics, Vol. 38, Issue 3, pp. 446-9, (1997) (PubMed).

Target Details for DNAJB1

Target: DNAJB1 (DnaJ (Hsp40) Homolog, Subfamily B, Member 1 (DNAJB1))

Alternative Name: HSP40

Background: DnaJ (Hsp40) belongs to the DnaJ-class of molecular chaperones with a C-terminal Zn finger domain. HSP40 (DnaJ) together with DnaK and GrpE form a molecular chaperone that is involved in formation of protein complexes, protein folding, prevention of protein aggregation, and protein turnover and export. Several human neurodegenerative diseases involve the expansion of a polyglutamine within the disease proteins. Molecular chaperones such as HSP40 complexes can modulate polyglutamine pathogenesis In transgenic Drosophila disease models of Machado-Joseph disease and Huntington disease Hdj1, the Drosophila homolog to human HSP40, demonstrates substrate specificity for polyglutamine proteins suppression in combination with other molecular chapterones of neurotoxicity, and altered solubility of mutant polyglutamine proteins.

Molecular Weight: 38044

NCBI Accession: NP_006136

UniProt: P25685