SSB antibody (N-Term)

Catalog No. ABIN1882133

Product Details anti-SSB Antibody

Target: SSB (Sjogren Syndrome Antigen B (SSB))

Binding Specificity: AA 66-96, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Predicted Reactivity: B

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-96 amino acids from the N-terminal region of human SSB.

Clone: RB17351

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SSB antibody (ABIN1882133)

Nitta, Tam, Kim, Fan: "The cellular protein La functions in enhancement of virus release through lipid rafts facilitated by murine leukemia virus glycosylated Gag." in: mBio, Vol. 2, Issue 1, pp. e00341-10, (2011) (PubMed).

Bitko, Musiyenko, Bayfield, Maraia, Barik: "Cellular La protein shields nonsegmented negative-strand RNA viral leader RNA from RIG-I and enhances virus growth by diverse mechanisms." in: Journal of virology, Vol. 82, Issue 16, pp. 7977-87, (2008) (PubMed).

Kotik-Kogan, Valentine, Sanfelice, Conte, Curry: "Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein." in: Structure (London, England : 1993), Vol. 16, Issue 6, pp. 852-62, (2008) (PubMed).

Target Details for SSB

Target: SSB (Sjogren Syndrome Antigen B (SSB))

Alternative Name: SSB (SSB Products)

Background: SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III -transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. This protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.

Molecular Weight: 46837

NCBI Accession: NP_003133

UniProt: P05455