STAM antibody (N-Term)

Catalog No. ABIN1882134

This anti-STAM antibody is a Rabbit Polyclonal antibody detecting STAM in WB. Suitable for Human and Mouse. This Primary Antibody has been cited in 1 publication.

Quick Overview for STAM antibody (N-Term) (ABIN1882134)

Target: STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAM antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB4633

Product Details anti-STAM Antibody

Binding Specificity: AA 1-30, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This STAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human STAM.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-STAM antibody (ABIN1882134)

Ortiz, Lee, Smith, Forman, Lee, Liu: "Comparative analyses of differentially induced T-cell receptor-mediated phosphorylation pathways in T lymphoma cells." in: Experimental biology and medicine (Maywood, N.J.), Vol. 235, Issue 12, pp. 1450-63, (2010) (PubMed).

Target Details for STAM

Target: STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))

Alternative Name: STAM

Background: Stimulation of cells with cytokines initiates a signal transduction cascade involving cytokine receptors, Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). STAM for 'signal-transducing adaptor molecule, induced after stimulation of cells with cytokine IL2, is a component of signal transduction downstream of JAK3.1 Human STAM cDNA cloned from a T-cell cDNA library encodes a 540-amino acid protein precipitated by anti-phosphotyrosine. Northern blot analysis indicates that STAM is expressed as a 2.9-kb message in a wide variety of tissue and cell types. The STAM sequence contains a Src-homology 3 (SH3) domain and an immunoreceptor tyrosine-based activation motif (ITAM). It has been suggested that STAM acts as an adaptor molecule in signal transduction pathways from cytokine receptors.

Molecular Weight: 59180

NCBI Accession: NP_003464

UniProt: Q92783

Pathways: EGFR Signaling Pathway, EGFR Downregulation