HDAC1 antibody

Catalog No. ABIN1882195

Product Details anti-HDAC1 Antibody

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HDAC1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Immunogen: Purified His-tagged HDAC1 protein was used to produced this monoclonal antibody.

Clone: 1061CT1-3-1

Isotype: IgM kappa

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-HDAC1 antibody (ABIN1882195)

Huynh, Fischle, Verdin, Bardwell: "BCoR, a novel corepressor involved in BCL-6 repression." in: Genes & development, Vol. 14, Issue 14, pp. 1810-23, (2000) (PubMed).

Sparrow, Miska, Langley, Reynaud-Deonauth, Kotecha, Towers, Spohr, Kouzarides, Mohun: "MEF-2 function is modified by a novel co-repressor, MITR." in: The EMBO journal, Vol. 18, Issue 18, pp. 5085-98, (1999) (PubMed).

Furukawa, Kawakami, Sudo, Inazawa, Matsumine, Akiyama, Nakamura: "Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae." in: Cytogenetics and cell genetics, Vol. 73, Issue 1-2, pp. 130-3, (1996) (PubMed).

Target Details for HDAC1

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Alternative Name: HDAC1 (HDAC1 Products)

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.

Molecular Weight: 55103

NCBI Accession: NP_004955

UniProt: Q13547

Pathways: Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis