Cytokeratin 18 antibody

Catalog No. ABIN1882229

The Mouse Monoclonal anti-Cytokeratin 18 antibody has been validated for WB. It is suitable to detect Cytokeratin 18 in samples from Human. There are 2+ publications available.

Quick Overview for Cytokeratin 18 antibody (ABIN1882229)

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cytokeratin 18 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 695CT17-2-6

Product Details anti-Cytokeratin 18 Antibody

Purification: This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This CYK18 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the 400-430 region of human CYK18.

Isotype: IgG3

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Cytokeratin 18 antibody (ABIN1882229)

Kulesh, Oshima: "Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells." in: Molecular and cellular biology, Vol. 8, Issue 4, pp. 1540-50, (1988) (PubMed).

Oshima, Millán, Ceceña: "Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation." in: Differentiation; research in biological diversity, Vol. 33, Issue 1, pp. 61-8, (1987) (PubMed).

Target Details for Cytokeratin 18

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Alternative Name: CYK18

Background: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Molecular Weight: 48058

NCBI Accession: NP_000215, NP_954657

UniProt: P05783

Pathways: Apoptosis, Caspase Cascade in Apoptosis