USP22 antibody

Catalog No. ABIN1882289

There are 3+ publications for this product available. The Mouse Monoclonal anti-USP22 antibody is suitable to detect USP22 in samples from Human. It has been validated for WB.

Quick Overview for USP22 antibody (ABIN1882289)

Target: USP22 (Ubiquitin Specific Peptidase 22 (USP22))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This USP22 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1154CT13-1-3-1

Product Details anti-USP22 Antibody

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified His-tagged USP22 protein was used to produced this monoclonal antibody.

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-USP22 antibody (ABIN1882289)

Zhao, Lang, Ito, Bonnet, Metzger, Sawatsubashi, Suzuki, Le Guezennec, Stunnenberg, Krasnov, Georgieva, Schüle, Takeyama, Kato, Tora, Devys: "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing." in: Molecular cell, Vol. 29, Issue 1, pp. 92-101, (2008) (PubMed).

Zhang, Varthi, Sykes, Phillips, Warzecha, Zhu, Wyce, Thorne, Berger, McMahon: "The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression." in: Molecular cell, Vol. 29, Issue 1, pp. 102-11, (2008) (PubMed).

Lee, Kim, Shin, Park, Chung, Baek: "The expression patterns of deubiquitinating enzymes, USP22 and Usp22." in: Gene expression patterns : GEP, Vol. 6, Issue 3, pp. 277-84, (2006) (PubMed).

Target Details for USP22

Target: USP22 (Ubiquitin Specific Peptidase 22 (USP22))

Alternative Name: USP22

Background: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Molecular Weight: 59961

NCBI Accession: NP_056091

UniProt: Q9UPT9