DC-SIGN/CD209 antibody (Extracellular Domain)

Catalog No. ABIN1885521

This anti-DC-SIGN/CD209 antibody is a Mouse Monoclonal antibody detecting DC-SIGN/CD209 in WB, IHC and ELISA. Suitable for Human.

Quick Overview for DC-SIGN/CD209 antibody (Extracellular Domain) (ABIN1885521)

Target: DC-SIGN/CD209 (CD209) (CD209)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DC-SIGN/CD209 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-DC-SIGN/CD209 Antibody

Binding Specificity: Extracellular Domain

Purification: Immunoaffinity chromotography purified IgG

Immunogen: Raised against a recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN (1).

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: -20 °C

Storage Comment: Can be stored at -20 °C, stable for one year.

Expiry Date: 12 months

Target Details for DC-SIGN/CD209

Target: DC-SIGN/CD209 (CD209) (CD209)

Alternative Name: DC-SIGN

Background: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes , where DCs hand over HIV to CD4+ T lymphocytes.DCs also amplify the amount of virus and extend the duration of viral infectivity.Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN.ICAM-3 is the natural ligand for DC-SIGN.A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently.DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR (8).The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
Synonyms: DC-SIGN (5D7), Dendritic cell-specific ICAM-3-grabbing nonintegrin 1

UniProt: Q9NNX6