TFIID(SI-1) (AA 158-339) antibody

Catalog No. ABIN1886075

The Rabbit Polyclonal anti-TFIID(SI-1) antibody is suitable to detect TFIID(SI-1) in samples from Human. It has been validated for IHC and WB.

Quick Overview for TFIID(SI-1) (AA 158-339) antibody (ABIN1886075)

Target: TFIID(SI-1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details

Binding Specificity: AA 158-339

Purification: Affinity purified by Protein A.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 158 and 339 of Human TBP

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details

Target: TFIID(SI-1)

Background: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides.The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs.TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.This gene encodes TBP, the TATA-binding protein.A distinctive feature of TBP is a long string of glutamines in the N-terminal.This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription.Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.[provided by RefSeq]
Synonyms: GTF2D, SCA17, TFIID, GTF2D1, MGC117320, MGC126054, MGC126055

Molecular Weight: 38 kDa

Gene ID: 6908

NCBI Accession: NP_003185, NM_003194