GALR2 antibody (AA 212-277)

Catalog No. ABIN1886197

This Rabbit Polyclonal antibody specifically detects GALR2 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for GALR2 antibody (AA 212-277) (ABIN1886197)

Target: GALR2 (Galanin Receptor 2 (GALR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GALR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GALR2 Antibody

Binding Specificity: AA 212-277

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 212 and 277 of Human GALR2

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for GALR2

Target: GALR2 (Galanin Receptor 2 (GALR2))

Alternative Name: galanin receptor 2

Background: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis.It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility.The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors.GALR2 interacts with the N-terminal residues of the galanin peptide.The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi.However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.[provided by RefSeq]

Molecular Weight: 42 kDa

Gene ID: 8811

NCBI Accession: NM_003857, NP_003848

Pathways: cAMP Metabolic Process, Inositol Metabolic Process, Feeding Behaviour