F13A1 antibody (AA 245-494)

Catalog No. ABIN1886255

The Rabbit Polyclonal anti-F13A1 antibody has been validated for WB and IF. It is suitable to detect F13A1 in samples from Human.

Quick Overview for F13A1 antibody (AA 245-494) (ABIN1886255)

Target: F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This F13A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-F13A1 Antibody

Binding Specificity: AA 245-494

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 245 and 494 of Human F13A1

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for F13A1

Target: F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

Alternative Name: Factor XIIIa

Background: This gene encodes the coagulation factor XIII A subunit.Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade.Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits.The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules.Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin.Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII.This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone.These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.[provided by RefSeq]

Molecular Weight: 83 kDa

Gene ID: 2162

NCBI Accession: NP_000120, NM_000129