RGS14 antibody (AA 504-566)

Catalog No. ABIN1886520

This anti-RGS14 antibody is a Rabbit Polyclonal antibody detecting RGS14 in WB and IHC. Suitable for Human.

Quick Overview for RGS14 antibody (AA 504-566) (ABIN1886520)

Target: RGS14 (Regulator of G-Protein Signaling 14 (RGS14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS14 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-RGS14 Antibody

Binding Specificity: AA 504-566

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 504 and 566 of Human RGS14

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for RGS14

Target: RGS14 (Regulator of G-Protein Signaling 14 (RGS14))

Alternative Name: RGS14

Background: This gene encodes a member of the regulator of G-protein signaling family.This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain.The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits.Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP.This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[provided by RefSeq]

Molecular Weight: 61 kDa

Gene ID: 10636

NCBI Accession: NM_006480, NP_006471

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Platelet-derived growth Factor Receptor Signaling