UNC13(C. Elegans)-Like (AA 680-927) antibody

Catalog No. ABIN1886614

This Rabbit Polyclonal antibody specifically detects UNC13(C. Elegans)-Like in IHC, WB and IF. It exhibits reactivity toward Human.

Quick Overview for UNC13(C. Elegans)-Like (AA 680-927) antibody (ABIN1886614)

Target: UNC13(C. Elegans)-Like

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Product Details

Binding Specificity: AA 680-927

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 680 and 927 of human UNC13B

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details

Target: UNC13(C. Elegans)-Like

Background: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia.The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain.Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia.Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.[provided by RefSeq]

Molecular Weight: 181 kDa

Gene ID: 10497

NCBI Accession: NP_006368, NM_006377