GNAS antibody (AA 716-968)

Catalog No. ABIN1886633

The Rabbit Polyclonal anti-GNAS antibody has been validated for WB and IHC. It is suitable to detect GNAS in samples from Human.

Quick Overview for GNAS antibody (AA 716-968) (ABIN1886633)

Target: GNAS (GNAS Complex Locus (GNAS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNAS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GNAS Antibody

Binding Specificity: AA 716-968

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 716 and 968 of Human GNAS

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for GNAS

Target: GNAS (GNAS Complex Locus (GNAS))

Alternative Name: XLalphas

Background: This locus has a highly complex imprinted expression pattern.It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons.Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression.An antisense transcript is produced from an overlapping locus on the opposite strand.One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region.In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex.Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses.Multiple transcript variants encoding different isoforms have been found for this gene.Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.[provided by RefSeq]
Synonyms: AHO, C20orf45, GNAS1, GPSA, GSA, GSP, MGC33735, PHP1A, PHP1B, POH, dJ309F20.1.1, dJ806M20.3.3

Molecular Weight: 111 kDa

Gene ID: 2778

NCBI Accession: NM_080425, NP_536350

Pathways: Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis