IPO7 antibody (AA 976-1038)

Catalog No. ABIN1886728

This Rabbit Polyclonal antibody specifically detects IPO7 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for IPO7 antibody (AA 976-1038) (ABIN1886728)

Target: IPO7 (Importin 7 (IPO7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IPO7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-IPO7 Antibody

Binding Specificity: AA 976-1038

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 976 and 1038 of Importin-7

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 1 x PBS, 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for IPO7

Target: IPO7 (Importin 7 (IPO7))

Alternative Name: Importin-7

Background: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal.The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta.Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin.This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions.At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.[provided by RefSeq]

Molecular Weight: 120 kDa

Gene ID: 10527

NCBI Accession: NM_006391, NP_006382

Pathways: Protein targeting to Nucleus