RYBP antibody (AA 215-228)

Catalog No. ABIN1886857

This Rabbit Polyclonal antibody specifically detects RYBP in WB, ELISA and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for RYBP antibody (AA 215-228) (ABIN1886857)

Target: RYBP (RING1 and YY1 Binding Protein (RYBP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RYBP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RYBP Antibody

Binding Specificity: AA 215-228

Purification: Affinity chromatography purified via peptide column

Immunogen: Synthetic peptide corresponding to amino acids 215 to 228 of human DEDAF the sequence is identical to that of mouse origin.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for RYBP

Target: RYBP (RING1 and YY1 Binding Protein (RYBP))

Alternative Name: DEDAF

Background: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain (DD) death effector domain (DED), and caspase recruitment domain (CARD) containing molecules.Several molecules including caspases and adaptor FADD contain DEDs.A novel protein that interacts with DED of caspase-8 and 10, and FADD was identified recently and designated DEDAF for DED associated factor.DEDAF is identical to the transcriptional repressor RYBP.DEDAF/RYBP is expressed in multiple tissues and cell lines.DEDAF interacts with FADD and augments the formation of CD95/FADD/capase-8 complexes at the cell membrane, and interacts with DED-containing DNA biding protein (DEDD) in the nucleus indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.

Molecular Weight: 32 kDa