BIRC7 antibody (AA 264-280, AA 281-298)

Catalog No. ABIN1886863

This Rabbit Polyclonal antibody specifically detects BIRC7 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for BIRC7 antibody (AA 264-280, AA 281-298) (ABIN1886863)

Target: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIRC7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-BIRC7 Antibody

Binding Specificity: AA 264-280, AA 281-298

Specificity: A lower but much weaker band at 30 kDa was detected in Raji cell lysate, which may represent the short form of Livin.

Purification: Affinity chromatography purified via peptide column

Immunogen: Livin antibody was raised with a Synthetic peptide corresponding to amino acids 264 to 280 of the short form and 281 to 298 of the long form of human Livin.This sequence is identical between a and b forms of the Livin proteins.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for BIRC7

Target: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Alternative Name: Livin

Background: Apoptosis, or programmed cell death, is related to many diseases, such as cancer.Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins.IAP proteins form a conserved gene family that binds to and inhibits cell death proteases.A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP.Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-alpha and Livin-beta.Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6.Livin has direct interaction with several caspases including caspase-3, -7, and -9.Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP.The two isoforms of Livin appear to have different functions and tissue distributions.
Synonyms: KIAP

Molecular Weight: 33 kDa

NCBI Accession: NP_071444