TRAF3IP2 antibody (AA 554-568)

Catalog No. ABIN1886888

The Rabbit Polyclonal anti-TRAF3IP2 antibody has been validated for WB, ELISA and IHC. It is suitable to detect TRAF3IP2 in samples from Human.

Quick Overview for TRAF3IP2 antibody (AA 554-568) (ABIN1886888)

Target: TRAF3IP2 (TRAF3 Interacting Protein 2 (TRAF3IP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF3IP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TRAF3IP2 Antibody

Binding Specificity: AA 554-568

Purification: Affinity chromatography purified via peptide column

Immunogen: Synthetic peptide corresponding to amino acids 554 to 568 of human CIKS.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for TRAF3IP2

Target: TRAF3IP2 (TRAF3 Interacting Protein 2 (TRAF3IP2))

Alternative Name: CIKS

Background: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses.NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli.NF-kappaB associates with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity.IkappaB is phosphorylated by IkappaB kinase (IKK) complex that contains IKKalpha, IKKbeta, and IKKgamma.A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-kappaB activator 1).CIKS directly interacts with IKKgamma.CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK).These results indicate that CIKS/Act1 is involved in the inflammation and stress responses.CIKS/Act1 is ubiquitously expressed in human tissues.
Synonyms: Act1

Molecular Weight: 63 kDa

Pathways: Production of Molecular Mediator of Immune Response