BNIP3L/NIX antibody (AA 77-92)

Catalog No. ABIN1886900

The Rabbit Polyclonal anti-BNIP3L/NIX antibody has been validated for WB, IHC and ELISA. It is suitable to detect BNIP3L/NIX in samples from Human.

Quick Overview for BNIP3L/NIX antibody (AA 77-92) (ABIN1886900)

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BNIP3L/NIX antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-BNIP3L/NIX Antibody

Binding Specificity: AA 77-92

Purification: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 77 to 92 of human origin, which are identical to those of mouse Bnip3L.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for BNIP3L/NIX

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Alternative Name: Bnip3L

Background: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death.Bcl-2 homology 3 (BH3) domain is a potent death domain.BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family.A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3alpha, and Nix (for Nip3-like protein X).Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3.Overexpression of Bnip3L induces apoptosis.Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL.Bnip3L is localized in mitochondria.The messenger RNA of Bnip3L is ubiquitously expressed in human tissues.Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.
Synonyms: Nix

Molecular Weight: 40 kDa

Pathways: Autophagy