IRGC antibody (N-Term)

Catalog No. ABIN1887842

The Rabbit Polyclonal anti-IRGC antibody has been validated for WB, ELISA and ICC. It is suitable to detect IRGC in samples from Human, Rat and Mouse.

Quick Overview for IRGC antibody (N-Term) (ABIN1887842)

Target: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRGC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-IRGC Antibody

Binding Specificity: N-Term

Specificity: Two isoforms of IRGC are known to exist, this antibody will only recognize the IRGCa isoform.

Purification: Affinity chromatography purified via peptide column

Immunogen: 13 amino acid peptide near the amino terminus of human IRGC.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for IRGC

Target: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Alternative Name: IRGC

Background: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens.IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans.Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs.In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines.As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
Synonyms: Immunity-related GTPase cinema 1, Interferon-inducible GTPase 5, Iigp5, CINEMA

NCBI Accession: NP_062558