FCGR3B antibody (N-Term)

Catalog No. ABIN1944735

Product Details anti-FCGR3B Antibody

Target: FCGR3B (Fc Fragment of IgG, Low Affinity IIIb, Receptor (CD16b) (FCGR3B))

Binding Specificity: AA 12-47, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FCGR3B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FCGR3B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 12-47 amino acids from the N-terminal region of human FCGR3B.

Clone: RB47719

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-FCGR3B antibody (ABIN1944735)

Ravetch, Perussia: "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions." in: The Journal of experimental medicine, Vol. 170, Issue 2, pp. 481-97, (1989) (PubMed).

Peltz, Grundy, Lebo, Yssel, Barsh, Moore: "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 3, pp. 1013-7, (1989) (PubMed).

Scallon, Scigliano, Freedman, Miedel, Pan, Unkeless, Kochan: "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 13, pp. 5079-83, (1989) (PubMed).

Simmons, Seed: "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein." in: Nature, Vol. 333, Issue 6173, pp. 568-70, (1988) (PubMed).

Target Details for FCGR3B

Target: FCGR3B (Fc Fragment of IgG, Low Affinity IIIb, Receptor (CD16b) (FCGR3B))

Alternative Name: FCGR3B (FCGR3B Products)

Background: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Molecular Weight: 26216

Gene ID: 2215

UniProt: O75015