ADRA2B antibody

Catalog No. ABIN1944814

This Rabbit Polyclonal antibody specifically detects ADRA2B in WB and IF. It exhibits reactivity toward Human and has been mentioned in 4+ publications.

Quick Overview for ADRA2B antibody (ABIN1944814)

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA2B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-ADRA2B Antibody

Isotype: IgG1

Application Details

Application Notes: IF: 1:100. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-ADRA2B antibody (ABIN1944814)

Cayla, Heinonen, Viikari, Schaak, Snapir, Bouloumié, Karvonen, Pesonen, Scheinin, Paris: "Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene." in: Biochemical pharmacology, Vol. 67, Issue 3, pp. 469-78, (2004) (PubMed).

Small, Brown, Forbes, Liggett: "Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4917-22, (2001) (PubMed).

Lomasney, Lorenz, Allen, King, Regan, Yang-Feng, Caron, Lefkowitz: "Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 13, pp. 5094-8, (1990) (PubMed).

Weinshank, Zgombick, Macchi, Adham, Lichtblau, Branchek, Hartig: "Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor." in: Molecular pharmacology, Vol. 38, Issue 5, pp. 681-8, (1990) (PubMed).

Target Details for ADRA2B

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Alternative Name: Adrenergic Receptor alpha-2B

Background: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Molecular Weight: 49954 Da

Gene ID: 151

UniProt: P18089

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process