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ADRA2B antibody

ADRA2B Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1944814
  • Target See all ADRA2B Antibodies
    ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))
    Reactivity
    • 22
    • 5
    • 4
    Human
    Host
    • 22
    • 2
    • 1
    Rabbit
    Clonality
    • 23
    • 2
    Polyclonal
    Conjugate
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ADRA2B antibody is un-conjugated
    Application
    • 16
    • 9
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Isotype
    IgG1
    Top Product
    Discover our top product ADRA2B Primary Antibody
  • Application Notes
    IF: 1:100. WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Storage
    4 °C,-20 °C
  • Cayla, Heinonen, Viikari, Schaak, Snapir, Bouloumié, Karvonen, Pesonen, Scheinin, Paris: "Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene." in: Biochemical pharmacology, Vol. 67, Issue 3, pp. 469-78, (2004) (PubMed).

    Small, Brown, Forbes, Liggett: "Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4917-22, (2001) (PubMed).

    Lomasney, Lorenz, Allen, King, Regan, Yang-Feng, Caron, Lefkowitz: "Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 13, pp. 5094-8, (1990) (PubMed).

    Weinshank, Zgombick, Macchi, Adham, Lichtblau, Branchek, Hartig: "Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor." in: Molecular pharmacology, Vol. 38, Issue 5, pp. 681-8, (1990) (PubMed).

  • Target
    ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))
    Alternative Name
    Adrenergic Receptor alpha-2B (ADRA2B Products)
    Synonyms
    ADRA2L1 antibody, ADRA2RL1 antibody, ADRARL1 antibody, ALPHA2BAR antibody, alpha-2BAR antibody, Adra-2b antibody, [a]2B antibody, alpha2-C2 antibody, alpha2B antibody, ADRA2B antibody, zgc:194747 antibody, Adra2b antibody, adrenoceptor alpha 2B antibody, adrenergic receptor, alpha 2b antibody, adrenergic, alpha-2B-, receptor antibody, adrenoceptor alpha 2C antibody, ADRA2B antibody, Adra2b antibody, ADRA2C antibody, adra2b antibody
    Background
    Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
    Molecular Weight
    49954 Da
    Gene ID
    151
    UniProt
    P18089
    Pathways
    EGFR Signaling Pathway, cAMP Metabolic Process
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