ErbB2/Her2 antibody (pSer1107)

Catalog No. ABIN1944841

This Rabbit Polyclonal antibody specifically detects ErbB2/Her2 in WB and DB. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for ErbB2/Her2 antibody (pSer1107) (ABIN1944841)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ErbB2/Her2 antibody is un-conjugated

Application: Western Blotting (WB), Dot Blot (DB)

Clone: RB40102

Product Details anti-ErbB2/Her2 Antibody

Binding Specificity: pSer1107

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1107 of human ERBB2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ErbB2/Her2 antibody (ABIN1944841)

Geradts, Bean, Bentley, Barry: "The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features." in: Cancer investigation, Vol. 28, Issue 9, pp. 969-77, (2010) (PubMed).

Zaoui, Benseddik, Daou, Salaün, Badache: "ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 43, pp. 18517-22, (2010) (PubMed).

Stackievicz, Paran, Bernheim, Shapira, Weisenberg, Kaufman, Klein, Gutman: "Prognostic significance of HER-2/neu expression in patients with ductal carcinoma in situ." in: The Israel Medical Association journal : IMAJ, Vol. 12, Issue 5, pp. 290-5, (2010) (PubMed).

Target Details for ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Alternative Name: ERBB2

Background: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Molecular Weight: 137910

Gene ID: 2064

NCBI Accession: NP_001005862, NP_004439

UniProt: P04626

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development