CREB1 antibody (AA 1-297)

Catalog No. ABIN1944898

This Mouse Monoclonal antibody specifically detects CREB1 in WB. It exhibits reactivity toward Human, Mouse and Rat and has been mentioned in 5+ publications.

Quick Overview for CREB1 antibody (AA 1-297) (ABIN1944898)

Target: CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CREB1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1335CT115-203-189

Product Details anti-CREB1 Antibody

Binding Specificity: AA 1-297

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This CREB1 antibody is generated from a mouse immunized with a recombinant protein from human CREB1.

Isotype: IgG1 kappa

Application Details

Application Notes: IHC: 1:500. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CREB1 antibody (ABIN1944898)

Waeber, Meyer, Hoeffler, Habener: "Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing." in: Transactions of the Association of American Physicians, Vol. 103, pp. 28-37, (1992) (PubMed).

Short, Manohar, Furtado, Ghadge, Wolinsky, Thimmapaya, Jungmann: "Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells." in: Nucleic acids research, Vol. 19, Issue 15, pp. 4290, (1991) (PubMed).

Berkowitz, Gilman: "Two distinct forms of active transcription factor CREB (cAMP response element binding protein)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 14, pp. 5258-62, (1990) (PubMed).

Yoshimura, Fujisawa, Yoshida: "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain." in: The EMBO journal, Vol. 9, Issue 8, pp. 2537-42, (1990) (PubMed).

Hoeffler, Meyer, Yun, Jameson, Habener: "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA." in: Science (New York, N.Y.), Vol. 242, Issue 4884, pp. 1430-3, (1989) (PubMed).

Target Details for CREB1

Target: CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

Alternative Name: CREB1

Background: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Molecular Weight: 35136

Gene ID: 1385

UniProt: P16220

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation