HSP90AA1 antibody (AA 229-263)

Catalog No. ABIN1945096

This Rabbit Polyclonal antibody specifically detects HSP90AA1 in WB and IHC (p). It exhibits reactivity toward Zebrafish (Danio rerio) and has been mentioned in 5+ publications.

Quick Overview for HSP90AA1 antibody (AA 229-263) (ABIN1945096)

Target: HSP90AA1 (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSP90AA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB47443

Product Details anti-HSP90AA1 Antibody

Binding Specificity: AA 229-263

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This hsp90a.1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 229-263 amino acids from the Central region of human (DANRE) hsp90a.1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:2000. WB: 1:1000. WB: 1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-HSP90AA1 antibody (ABIN1945096)

Howe, Clark, Torroja, Torrance, Berthelot, Muffato, Collins, Humphray, McLaren, Matthews, McLaren, Sealy, Caccamo, Churcher, Scott, Barrett, Koch, Rauch, White, Chow, Kilian, Quintais, Guerra-Assunção, Zhou, Gu, Yen, Vogel, Eyre, Redmond, Banerjee, Chi, F: "The zebrafish reference genome sequence and its relationship to the human genome." in: Nature, Vol. 496, Issue 7446, pp. 498-503, (2013) (PubMed).

Etard, Roostalu, Strähle: "Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril." in: The Journal of cell biology, Vol. 180, Issue 6, pp. 1163-75, (2008) (PubMed).

Etard, Behra, Fischer, Hutcheson, Geisler, Strähle: "The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis." in: Developmental biology, Vol. 308, Issue 1, pp. 133-43, (2007) (PubMed).

Lele, Hartson, Martin, Whitesell, Matts, Krone: "Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90." in: Developmental biology, Vol. 210, Issue 1, pp. 56-70, (1999) (PubMed).

Krone, Sass: "HSP 90 alpha and HSP 90 beta genes are present in the zebrafish and are differentially regulated in developing embryos." in: Biochemical and biophysical research communications, Vol. 204, Issue 2, pp. 746-52, (1994) (PubMed).

Target Details for HSP90AA1

Target: HSP90AA1 (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1))

Alternative Name: hsp90a.1

Background: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Plays a key role in slow and fast muscle development in the embryo. Plays a role in myosin expression and assembly.

Molecular Weight: 83319

Gene ID: 30591

UniProt: Q90474

Pathways: M Phase, Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals