HMGA2 antibody (C-Term)

Catalog No. ABIN1981306

This Rabbit Polyclonal antibody specifically detects HMGA2 in WB and FACS. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for HMGA2 antibody (C-Term) (ABIN1981306)

Target: HMGA2 (High Mobility Group AT-Hook 2 (HMGA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMGA2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB21014

Product Details anti-HMGA2 Antibody

Binding Specificity: AA 64-92, C-Term

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HMGA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the C-terminal region of human HMGA2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-HMGA2 antibody (ABIN1981306)

Luo, Li, Ge, Mei, Zhao, Jiang, Geng, Li, Yao, Cao: "HMGA2 upregulation mediates Cd-induced migration and invasion in A549 cells and in lung tissues of mice." in: Chemico-biological interactions, Vol. 277, pp. 1-7, (2017) (PubMed).

Target Details for HMGA2

Target: HMGA2 (High Mobility Group AT-Hook 2 (HMGA2))

Alternative Name: HMGA2

Background: This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Molecular Weight: 11832

Gene ID: 8091

NCBI Accession: NP_003474, NP_003475

UniProt: P52926

Pathways: Positive Regulation of Response to DNA Damage Stimulus