C3 antibody (FITC)

Catalog No. ABIN1991903

The Rabbit Polyclonal anti-C3 antibody has been validated for WB and ELISA. It is suitable to detect C3 in samples from Mouse.

Quick Overview for C3 antibody (FITC) (ABIN1991903)

Target: C3 (Complement Component 3 (C3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C3 antibody is conjugated to FITC

Application: Western Blotting (WB), ELISA

Product Details anti-C3 Antibody (FITC)

Purification: Caprylic Acid Ammonium Sulfate Precipitation

Immunogen: Recombinant mouse Complement C3 protein

Isotype: IgG

Application Details

Application Notes: Optimal working concentration should be determinde by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.03 % Proclin 300, 53 % Glycerol, 0.01 M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C/-80 °C

Storage Comment: Upon delivery aliquot and store at -20 °C or -80 °C.

Target Details for C3

Target: C3 (Complement Component 3 (C3))

Alternative Name: Complement C3

Background: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. The short isoform hasB-cell stimulatory activity. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2.
Synonyms: HSE-MSF,ASP,C3adesArg,C3

UniProt: P01027

Pathways: Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling