ADAM15 antibody (AA 207-452) (FITC)

Catalog No. ABIN1992070

This Rabbit Polyclonal antibody specifically detects ADAM15 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for ADAM15 antibody (AA 207-452) (FITC) (ABIN1992070)

Target: ADAM15 (ADAM Metallopeptidase Domain 15 (ADAM15))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAM15 antibody is conjugated to FITC

Application: Western Blotting (WB), ELISA

Product Details anti-ADAM15 Antibody (FITC)

Binding Specificity: AA 207-452

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Disintegrin and metalloproteinase domain-containing protein 15 protein (207-452AA)

Isotype: IgG

Application Details

Application Notes: Optimal working concentration should be determinde by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ADAM15

Target: ADAM15 (ADAM Metallopeptidase Domain 15 (ADAM15))

Alternative Name: ADAM15

Background:

Background: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

Aliases: A disintegrin and metalloproteinase domain 15 (metargidin) antibody, A disintegrin and metalloproteinase domain 15 antibody, ADA15_HUMAN antibody, ADAM 15 antibody, ADAM metallopeptidase domain 15 antibody, Adam15 antibody, and cysteine-rich protein 15 antibody, Disintegrin and metalloproteinase domain-containing protein 15 antibody, disintegrin-like antibody, EC 3.4.24. antibody, MDC 15 antibody, MDC-15 antibody, MDC15 antibody, Metalloprotease RGD disintegrin protein antibody, Metalloproteinase like disintegrin like and cysteine rich protein 15 antibody, Metalloproteinase-like antibody, Metargidin antibody

UniProt: Q13444