Histone H3.3 antibody (AA 2-136) (FITC)

Catalog No. ABIN1992626

The Rabbit Polyclonal anti-Histone H3.3 antibody has been validated for ELISA and WB. It is suitable to detect Histone H3.3 in samples from Human.

Quick Overview for Histone H3.3 antibody (AA 2-136) (FITC) (ABIN1992626)

Target: Histone H3.3 (H3F3A) (H3 Histone, Family 3A (H3F3A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Histone H3.3 antibody is conjugated to FITC

Application: ELISA, Western Blotting (WB)

Product Details anti-Histone H3.3 Antibody (FITC)

Binding Specificity: AA 2-136

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Histone H3.3 protein (2-136AA)

Isotype: IgG

Application Details

Application Notes: Optimal working concentration should be determinde by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Histone H3.3

Target: Histone H3.3 (H3F3A) (H3 Histone, Family 3A (H3F3A))

Alternative Name: H3F3A

Background:

Background: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Aliases: H3 histone family 3A antibody, H3 histone family 3B antibody, H3 histone, family 3B (H3.3B) antibody, H3.3 antibody, H3.3A antibody, H3.3B antibody, H33_HUMAN antibody, H3F3 antibody, H3F3A antibody, H3f3b antibody, Histone H3.3 antibody, Histone H3.3Q antibody, Histone H3.A antibody, Histone H3.B antibody, MGC87782 antibody, MGC87783 antibody

UniProt: P84243