Glyco Protein G antibody

Catalog No. ABIN1993838

Product Details

Target: Glyco Protein G

Reactivity: Rabies Virus

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Caprylic Acid Ammonium Sulfate Precipitation

Immunogen: Recombinant Rabies virus Glycoprotein G protein

Isotype: IgG

Application Details

Application Notes: Optimal working concentration should be determinde by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.03 % Proclin 300, 53 % Glycerol, 0.01 M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C/-80 °C

Storage Comment: Upon delivery aliquot and store at -20 °C or -80 °C.

References

Starodubova, Kuzmenko, Pankova, Latanova, Preobrazhenskaya, Karpov: "[A DNA Construct That Encodes the Rabies Virus Consensus Glycoprotein with a Proteasome Degradation Signal Induces Antibody Production with IgG2A Subtype Predominance]." in: Molekuliarnaia biologiia, Vol. 52, Issue 3, pp. 527-532, (2018) (PubMed).

Target Details

Target: Glyco Protein G

Synonyms: transmembrane glycoprotein G antibody, RABVgp4 antibody

Target Type: Viral Protein

Background: Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein G and thereby facilitate rabies virus entry into cells.
Synonyms: G

UniProt: P03524