Clusterin antibody

Catalog No. ABIN205727

The Rabbit Polyclonal anti-Clusterin antibody is suitable to detect Clusterin in samples from Human. It has been validated for WB.

Quick Overview for Clusterin antibody (ABIN205727)

Target: Clusterin (CLU)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Clusterin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Clusterin Antibody

Specificity: Recognizes human clusterin, also known as apolipoprotein J, Ku70-binding protein 1 or TRPM-2. Clusterin is a ubiquitous glycoprotein which exists in at least two distinct isoforms, a proapoptotic nuclear form, of 49kD, and a prosurvival secretory form with a molecular weight of 75-80kD. Clusterin is implicated in several diverse physiological processes including sperm maturation, cell differentiation, and apoptosis. Clusterin upregulation has been reported in various human malignancies, including bladder, prostate, and breast tumors. Following specific stress induced injury, secretory clusterin acts as a molecular chaperone, scavenging denatured proteins outside cells. It has been shown to be upregulated in Alzheimer's€™s disease (Chen et al. 2012), retinitis pigmentosa (Jobes et al 1993), glomerulonephritis, atherosclerosis and myocardial infarction (Rosenberg et al. 2002).

Purification: Purified

Immunogen: Recombinant human clusterin isoform 1.

Type of Immunogen: Recombinant protein

Isotype: IgG

Application Details

Application Notes: Approved: WB (0.5 - 1 μg/mL)

Usage: Western Blot: LS-C42331 detects a band of approximately 60kD in human brain tissue lysate.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for Clusterin

Target: Clusterin (CLU)

Alternative Name: CLU / Clusterin

Background: Name/Gene ID: CLU

Synonyms: CLU, APO-J, Apolipoprotein J, CLU1, Clusterin, Complement lysis inhibitor, CLI, AAG4, Aging-associated protein 4, Ku70-binding protein 1, KUB1, SGP2, APOJ, SGP-2, Sulfated glycoprotein 2, CLU2, Complement cytolysis inhibitor, NA1/NA2, SP-40

Gene ID: 1191

UniProt: P10909

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling