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Complement Factor H antibody

CFH Reactivity: Human WB, IHC, ELISA, FACS, IHC (fro) Host: Mouse Monoclonal unconjugated
Catalog No. ABIN206665
  • Target See all Complement Factor H (CFH) Antibodies
    Complement Factor H (CFH)
    Reactivity
    • 66
    • 25
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 58
    • 15
    • 4
    • 1
    Mouse
    Clonality
    • 55
    • 23
    Monoclonal
    Conjugate
    • 37
    • 9
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Complement Factor H antibody is un-conjugated
    Application
    • 62
    • 25
    • 15
    • 14
    • 13
    • 12
    • 11
    • 10
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    Recognizes human complement factor H which exists in 2 forms. The most common form, of 150 kD, and the less common form of 43 kD. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.
    Purification
    Protein A purified
    Immunogen
    Purified human factor H from serum.
    Isotype
    IgG1
    Top Product
    Discover our top product CFH Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Target Species of Antibody: Human

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Borate buffered saline,  pH 8.4, 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C,-20 °C
    Storage Comment
    4°C or -20°C, Avoid freeze-thaw cycles.
  • Target
    Complement Factor H (CFH)
    Alternative Name
    CFH / Complement Factor H (CFH Products)
    Synonyms
    AHUS1 antibody, AMBP1 antibody, ARMD4 antibody, ARMS1 antibody, CFHL3 antibody, FH antibody, FHL1 antibody, HF antibody, HF1 antibody, HF2 antibody, HUS antibody, Mud-1 antibody, NOM antibody, Sas-1 antibody, Sas1 antibody, Fh antibody, CFH antibody, im:7147412 antibody, si:ch211-207o17.2 antibody, fH antibody, armd4 antibody, arms1 antibody, cfh antibody, cfhl3 antibody, fhl1 antibody, hf1 antibody, hf2 antibody, hus antibody, complement factor H antibody, complement component factor h antibody, complement factor H-related protein 5 antibody, complement factor H L homeolog antibody, CFH antibody, Cfh antibody, cfh antibody, LOC100399888 antibody, LOC100733902 antibody, cfh.L antibody
    Background
    Name/Gene ID: CFH

    Synonyms: CFH, Adrenomedullin binding protein, AHUS1, AMBP1, ARMS1, ARMD4, Beta-1-H-globulin, Factor H, Factor H-like 1, HF, HF2, H factor 1, H factor 2 (complement), HUS, HF1, Beta-1H, CFHL3, Complement factor H, H factor 1 (complement)
    Gene ID
    3075
    UniProt
    P08603
    Pathways
    Complement System, Cellular Response to Molecule of Bacterial Origin
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