Cathelicidin antibody (PE)

Catalog No. ABIN2172291

This anti-Cathelicidin antibody is a Rabbit Polyclonal antibody detecting Cathelicidin in FACS. Suitable for Mouse and Rat.

Quick Overview for Cathelicidin antibody (PE) (ABIN2172291)

Target: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathelicidin antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-Cathelicidin Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Calicidin

Isotype: IgG

Application Details

Application Notes: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C for 12 months.

Target Details for Cathelicidin

Target: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Alternative Name: Cathelicidin

Background: Cathelicidins are a family of antimicrobial proteins found in the peroxidase-negative granules of neutrophils. Along with the family of proteins known as defensins, cathelicidins participate in the first line of defense by preventing local infection and systemic invasion of microbes. FALL-39 precursor (FALL-39 peptide antibiotic, cationic anti-microbial protein, CAMP, CAP-18, HSD26) is a cathelicidin anti-microbial protein that contains the antibacterial peptide LL-37 (amino acids 134-170). In contrast to the defensins, which are cysteine-rich peptides that fold in β-pleated sheets, LL-37 is a cysteine-free peptide that can adopt an amphipathic å,-helical conformation. LL-37 binds to bacterial lipopolysaccharides (LPS) and is a potent chemotactic factor for recruiting mast cells to sites of inflammation. LL-37 is present in inflammatory skin diseases that include psoriasis, sub-acute lupus erthematosus, dermatitis and nickel contact hypersensitivity. It is not found in normal skin epidermis. The secreted protein is expressed primarily in bone marrow, testis and neutrophils. The mouse and rat ortholog, CRAMP (cathelin-related antimicrobial peptide), is also part of the cathelicidin family of host defense peptides. These include precursors of potent antimicrobial peptides that direct antimicrobial activity against various microbial pathogens and also activate mesenchymal cells during wound repair. CRAMP is expressed in testis, spleen, stomach and intestine.
Synonyms: 18 kDa cationic antimicrobial protein, Antibacterial protein FALL-39, Antibacterial protein LL-37, CAMP, CRAMP_MOUSE, CAP 18, CAP-18, CAP18, cathelicidin antimicrobial peptide, Cathelicidin antimicrobial peptide precursor, Cathelin-like protein, Cathelin-related antimicrobial peptide, CATHL3, Cationic antimicrobial protein CAP 18, Cationic antimicrobial protein, 18-KD, CLP, Cnlp, Cramp, CRAMP, mouse, homolog of, FALL 39, FALL 39 peptide antibiotic, FALL-39 peptide antibiotic, FALL39, hCAP 18, hCAP-18, hCAP18, HSD26, LL 37, LL37, MCLP, mcramp, Peptide antibiotic, PR-39, porcine, homolog of, SOB3.

Pathways: Cellular Response to Molecule of Bacterial Origin