Claudin 15 antibody (AbBy Fluor® 647)

Catalog No. ABIN2173127

The Rabbit Polyclonal anti-Claudin 15 antibody has been validated for WB. It is suitable to detect Claudin 15 in samples from Human, Mouse and Rat.

Quick Overview for Claudin 15 antibody (AbBy Fluor® 647) (ABIN2173127)

Target: Claudin 15 (CLDN15)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 15 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB)

Product Details anti-Claudin 15 Antibody (AbBy Fluor® 647)

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Claudin 15

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Claudin 15

Target: Claudin 15 (CLDN15)

Alternative Name: Claudin 15

Background:

Synonyms: Claudin-15, CLD15_HUMAN, CLDN15.

Background: The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-15 is a 228 amino acid multi-pass membrane protein that belongs to the claudin family and plays an important role in cell-adhesion activity and tight junction-specific events.

Pathways: Cell-Cell Junction Organization, Hepatitis C