CTNNA3 antibody (AA 131-230)

Catalog No. ABIN2173430

The Rabbit Polyclonal anti-CTNNA3 antibody has been validated for WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) and ICC. It is suitable to detect CTNNA3 in samples from Human.

Quick Overview for CTNNA3 antibody (AA 131-230) (ABIN2173430)

Target: CTNNA3 (Catenin (Cadherin-Associated Protein), alpha 3 (CTNNA3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTNNA3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Product Details anti-CTNNA3 Antibody

Binding Specificity: AA 131-230

Predicted Reactivity: Human,Mouse,Rat,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CTNNA3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CTNNA3

Target: CTNNA3 (Catenin (Cadherin-Associated Protein), alpha 3 (CTNNA3))

Alternative Name: CTNNA3

Background:

Synonyms: 4930429L08Rik, 4933408A16, Alpha catenin like protein, Alpha T catenin, Alpha T-catenin, Cadherin associated protein, Cadherin-associated protein, Catenin alpha 3, Catenin alpha-3, Catna3, CTNA3_HUMAN, CTNNA3, MGC26194, MGC75041, OTTHUMP00000019684, OTTMUSP00000028119, OTTMUSP00000028120, RP11-433J16.1, VR22.

Background: The catenins are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantally expressed in cardiomyocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer's disease (LOAD) as well as to dilated cardiomyopathy.