GPR161 antibody (AA 121-220) (Cy3)

Catalog No. ABIN2174757

This anti-GPR161 antibody is a Rabbit Polyclonal antibody detecting GPR161 in WB, IF (cc) and IF (p). Suitable for Human.

Quick Overview for GPR161 antibody (AA 121-220) (Cy3) (ABIN2174757)

Target: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR161 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-GPR161 Antibody (Cy3)

Binding Specificity: AA 121-220

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GPR161

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GPR161

Target: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Alternative Name: Gpr161

Background:

Synonyms: RE2, G-protein coupled receptor 161, G-protein coupled receptor RE2, GPR161

Background: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Gene ID: 23432

UniProt: Q8N6U8

Pathways: cAMP Metabolic Process