GPR37L1 antibody (AA 101-200) (Cy7)

Catalog No. ABIN2174810

The Rabbit Polyclonal anti-GPR37L1 antibody has been validated for IF (cc) and IF (p). It is suitable to detect GPR37L1 in samples from Human.

Quick Overview for GPR37L1 antibody (AA 101-200) (Cy7) (ABIN2174810)

Target: GPR37L1 (G Protein-Coupled Receptor 37 Like 1 (GPR37L1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR37L1 antibody is conjugated to Cy7

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-GPR37L1 Antibody (Cy7)

Binding Specificity: AA 101-200

Predicted Reactivity: Human,Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GPR37L1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GPR37L1

Target: GPR37L1 (G Protein-Coupled Receptor 37 Like 1 (GPR37L1))

Alternative Name: Gpr37l1

Background:

Synonyms: Endothelin B receptor-like protein 2, ET(B)R-LP-2, ETBR-LP-2, ETBR2, ETBRLP2, G-protein coupled receptor 37-like 1, GPR37L1, ETBR2_HUMAN.

Background: G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. Regulates baseline blood pressure in females and protects against cardiovascular stress in males. Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity.

Gene ID: 9283

UniProt: O60883