Phospholamban antibody (pSer16) (PE)

Catalog No. ABIN2178506

The Rabbit Polyclonal anti-Phospholamban antibody has been validated for FACS. It is suitable to detect Phospholamban in samples from Human, Rat and Mouse.

Quick Overview for Phospholamban antibody (pSer16) (PE) (ABIN2178506)

Target: Phospholamban (PLN)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholamban antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-Phospholamban Antibody (PE)

Binding Specificity: pSer16

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Cardiac phospholamban around the phosphorylation site of Ser16

Isotype: IgG

Application Details

Application Notes: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C for 12 months.

Target Details for Phospholamban

Target: Phospholamban (PLN)

Alternative Name: Plb

Background: Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) . Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 (CMH18) . CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Synonyms: Phospholamban phospho S16, p-Phospholamban phospho S16, p-PLBS16, Cardiac phospholamban, CMD1P, PLB, PLN, PPLA_HUMAN.

Gene ID: 5350

Pathways: Negative Regulation of Transporter Activity