CD55 antibody

Catalog No. ABIN2191983

The Mouse Monoclonal anti-CD55 antibody (Clone D17) (ABIN2191983) specifically detects CD55 in WB and FACS. The antibody is reactive with Human samples.

Quick Overview for CD55 antibody (ABIN2191983)

Target: CD55 (Complement Decay-Accelerating Factor (CD55))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD55 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: D17

Product Details anti-CD55 Antibody

Sterility: 0.2 μm filtered

Application Details

Application Notes: For flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

Target Details for CD55

Target: CD55 (Complement Decay-Accelerating Factor (CD55))

Alternative Name: Cd55, Daf

Background: CD55, also designated decay accelerating factor (DAF), is a 60-70 kDa glycosyl-phosphatidylinositol (GPI) anchored protein. CD55 is a member of the family of proteins that protect host tissue from damage by autologous complement. CD55 was first recognized as a species restricting factor operating at the level of C3 activation. It binds C3b and C4b to inhibit formation and half-life of the C3 convertases. CD55 expression increases upon T cell activation and in the presence of phorbol esters antibodies to CD55 (e.g. monoclonal antibody D17) are mitogenic. CD55 is broadly distributed among cells in contact with serum, including both haematopoietic and non- haematopoietic cells. Although CD55 does not have an essential role in controlling hemolysis of erythrocytes, it has an important role in regulation of the deposition of C3 on nucleated cells. Aliases DAF (decay accelerating factor)

Pathways: Complement System, Regulation of Leukocyte Mediated Immunity