Transferrin Receptor antibody

Catalog No. ABIN2192003

The Mouse Monoclonal anti-Transferrin Receptor antibody has been validated for FACS, WB, IP, IHC (fro) and IA. It is suitable to detect Transferrin Receptor in samples from Human. There is 1 publication available.

Quick Overview for Transferrin Receptor antibody (ABIN2192003)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)

Clone: 3B8 2A1

Product Details anti-Transferrin Receptor Antibody

Sterility: 0.2 μm filtered

Application Details

Application Notes: For Western blotting, flow cytometry and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

References for anti-Transferrin Receptor antibody (ABIN2192003)

Vogt, Blackwell, Giannetti, Bjorkman, Enns: "Heterotypic interactions between transferrin receptor and transferrin receptor 2." in: Blood, Vol. 101, Issue 5, pp. 2008-14, (2003) (PubMed).

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Background: Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45 % identity with TfR2.

Pathways: Transition Metal Ion Homeostasis