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BCR antibody

BCR Reactivity: Human IF, IHC (p), IA Host: Mouse Monoclonal CML26 unconjugated
Catalog No. ABIN2192147
  • Target See all BCR Antibodies
    BCR (Breakpoint Cluster Region (BCR))
    Reactivity
    • 116
    • 76
    • 33
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 108
    • 12
    • 4
    Mouse
    Clonality
    • 112
    • 12
    Monoclonal
    Conjugate
    • 57
    • 10
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This BCR antibody is un-conjugated
    Application
    • 66
    • 39
    • 36
    • 30
    • 26
    • 26
    • 18
    • 14
    • 10
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoassay (IA)
    Cross-Reactivity (Details)
    Cross reactivity: Multispecies : Yes
    Sterility
    0.2 μm filtered
    Clone
    CML26
    Isotype
    IgG1
    Top Product
    Discover our top product BCR Primary Antibody
  • Application Notes
    For immunohistochemistry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Intramyocardial arteries control
    Restrictions
    For Research Use only
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Bruynzeel, Abou El Hassan, Schalkwijk, Berkhof, Bast, Niessen, van der Vijgh: "Anti-inflammatory agents and monoHER protect against DOX-induced cardiotoxicity and accumulation of CML in mice." in: British journal of cancer, Vol. 96, Issue 6, pp. 937-43, (2007) (PubMed).

    Ciapaite, Bakker, Van Eikenhorst, Wagner, Teerlink, Schalkwijk, Fodor, Ouwens, Diamant, Heine, Westerhoff, Krab: "Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats." in: Biochimica et biophysica acta, Vol. 1772, Issue 3, pp. 307-16, (2007) (PubMed).

    Baidoshvili, Krijnen, Kupreishvili, Ciurana, Bleeker, Nijmeijer, Visser, Visser, Meijer, Stooker, Eijsman, van Hinsbergh, Hack, Niessen, Schalkwijk: "N(epsilon)-(carboxymethyl)lysine depositions in intramyocardial blood vessels in human and rat acute myocardial infarction: a predictor or reflection of infarction?" in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, Issue 11, pp. 2497-503, (2006) (PubMed).

    van Heijst, Niessen, Musters, van Hinsbergh, Hoekman, Schalkwijk: "Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis." in: Cancer letters, Vol. 241, Issue 2, pp. 309-19, (2006) (PubMed).

    Sommeijer, Beganovic, Schalkwijk, Ploegmakers, van der Loos, van Aken, ten Cate, van der Wal: "More fibrosis and thrombotic complications but similar expression patterns of markers for coagulation and inflammation in symptomatic plaques from DM2 patients." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 52, Issue 9, pp. 1141-9, (2004) (PubMed).

  • Target
    BCR (Breakpoint Cluster Region (BCR))
    Alternative Name
    Cml (BCR Products)
    Synonyms
    si:dkey-83d9.7 antibody, zK83D9.7 antibody, BCR antibody, ALL antibody, BCR1 antibody, CML antibody, D22S11 antibody, D22S662 antibody, PHL antibody, 5133400C09Rik antibody, AI561783 antibody, AI853148 antibody, mKIAA3017 antibody, breakpoint cluster region antibody, BCR, RhoGEF and GTPase activating protein antibody, bcr antibody, BCR antibody, Bcr antibody
    Background
    The monoclonal antibody CML26 recognizes human CML (carboxymethyl-lysine). CML is known to be formed from the oxidation of both carbohydrates and lipids. This makes CML a biomarker of general oxidative stress. Carboxymethyl-lysine (CML) is a well-characterized glycoxidation product that accumulates in tissues with age, and its rate of accumulation is accelerated in diabetes. Glycoxidation products are a subset of advanced glycation endproducts (AGEs) that are formed by the nonenzymatic glycation and subsequent irreversible oxidation of proteins. Oxidative stress and protein modification have been implicated in the pathogenesis of the chronic complications of diabetes, including nephropathy and atherosclerosis. The accumulation of CML in long-lived tissue such as skin collagen reflects oxidative stress over an extended period of the life-span, and has been shown to be greater in patients with diabetic complications than those without complications. Immunogen CML-KLH
    Pathways
    Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
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