IKbIP antibody

Catalog No. ABIN2423646

This Rabbit Polyclonal antibody specifically detects IKbIP in IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for IKbIP antibody (ABIN2423646)

Target: IKbIP (Inhibitor of KB Kinase beta Interacting Protein (IKbIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IKbIP antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-IKbIP Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human IKBIP

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IKbIP

Target: IKbIP (Inhibitor of KB Kinase beta Interacting Protein (IKbIP))

Alternative Name: IKBIP

Background: IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus and skeletal muscle.