tau antibody (pThr217)

Catalog No. ABIN2443974

The Rabbit Polyclonal anti-tau antibody (ABIN2443974) specifically detects tau in WB, ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for tau antibody (pThr217) (ABIN2443974)

Target: tau (tau Protein)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This tau antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-tau Antibody

Binding Specificity: pThr217

Purpose: Phospho-Tau (thr 217) Rabbit Polyclonal Antibody

Specificity: The antibody recognizes the human Phospho-Tau protein peptide at the Threonine 217 (Thr 217) phosphorylation site. (MW 48-67 kDa)

Purification: Immunogen affinity purified

Immunogen: Peptide phosphorylated at Thr 217

Application Details

Application Notes: IHC 1:1000

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: If reconstituted with deionized water in 50 μL: WB: 1:10000, IHC 1:1000. Optimal dilution has to be determined by the user.

Buffer: Lyophilized immunogen affinity purified in PBS pH 7.4

Preservative: Without preservative

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Expiry Date: 24 months

Target Details for tau

Target: tau (tau Protein)

Alternative Name: tau

Background: Tauopathies are a group of diverse dementias and movement disorders which have a common pathological feature in that they all display the presence of intracellular accumulation of abnormal filaments of tau protein. Furthermore, these accumulated tau proteins all display an abnormal phosphorylation pattern that may be disease specific. As an example, Amyotrophic lateral sclerosis (ALS, also referred to as Charcot's disease or Lou Gehrig's disease) is the most common form of progressive motor neuron disease in North America. ALS gradually disables the patient's voluntary motor muscle control until it becomes fatal.

UniProt: P10636