SGCB antibody

Catalog No. ABIN2458826

The Rabbit Polyclonal anti-SGCB antibody is suitable to detect SGCB in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for SGCB antibody (ABIN2458826)

Target: SGCB (Sarcoglycan, beta (43kDa Dystrophin-Associated Glycoprotein) (SGCB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGCB antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SGCB Antibody

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SGCB.

Application Details

Application Notes: SGCB antibody can be used for detection of SGCB by ELISA at 1:312500. SGCB antibody can be used for detection of SGCB by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SGCB antibody at -20 °C.

Target Details for SGCB

Target: SGCB (Sarcoglycan, beta (43kDa Dystrophin-Associated Glycoprotein) (SGCB))

Alternative Name: SGCB

Background: SGCB is a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix.The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural linkage between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. There are 3 main subcomplexes of the DGC: the cytoplasmic proteins dystrophin (DMD, MIM 300377) and syntrophin (SNTA1, MIM 601017), the alpha- and beta-dystroglycans (see MIM 128239), and the sarcoglycans (see, e.g., SGCA, MIM 600119) (Crosbie et al., 2000 [PubMed 10942431]).

Molecular Weight: 35 kDa

Gene ID: 6443

NCBI Accession: NP_000223

UniProt: Q16585

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location