PCDHGB1 antibody

Catalog No. ABIN2459281

This Rabbit Polyclonal antibody specifically detects PCDHGB1 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for PCDHGB1 antibody (ABIN2459281)

Target: PCDHGB1 (Protocadherin gamma Subfamily B, 1 (PCDHGB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PCDHGB1 Antibody

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PCDHGB1.

Application Details

Application Notes: PCDHGB1 antibody can be used for detection of PCDHGB1 by ELISA at 1:62500. PCDHGB1 antibody can be used for detection of PCDHGB1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PCDHGB1 antibody at -20 °C.

Target Details for PCDHGB1

Target: PCDHGB1 (Protocadherin gamma Subfamily B, 1 (PCDHGB1))

Alternative Name: PCDHGB1

Background: PCDHGB1 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHGB1 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Molecular Weight: 85 kDa

Gene ID: 56104

NCBI Accession: NP_115266

UniProt: Q3SY75