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BCL2L1 antibody

This anti-BCL2L1 antibody is a Rabbit Polyclonal antibody detecting BCL2L1 in WB and ELISA. Suitable for Human and Dog.
Catalog No. ABIN2460189

Quick Overview for BCL2L1 antibody (ABIN2460189)

Target

See all BCL2L1 Antibodies
BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivity

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Human, Dog

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This BCL2L1 antibody is un-conjugated

Application

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Western Blotting (WB), ELISA
  • Purification

    Antibody is purified by protein A chromatography method.

    Immunogen

    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human BCL2L1.
  • Application Notes

    BCL2L1 antibody can be used for detection of BCL2L1 by ELISA at 1:312500. BCL2L1 antibody can be used for detection of BCL2L1 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

    Concentration

    1 mg/mL

    Buffer

    Antibody is lyophilized in PBS buffer with 2 % sucrose.

    Handling Advice

    As with any antibody avoid repeat freeze-thaw cycles.

    Storage

    4 °C/-20 °C

    Storage Comment

    For short periods of storage (days) store at 4 °C. For longer periods of storage, store BCL2L1 antibody at -20 °C.
  • Target

    BCL2L1 (BCL2-Like 1 (BCL2L1))

    Alternative Name

    BCL2L1

    Background

    BCL2L1 encodes a protein which belongs to the BCL-2 protein family. The proteins encoded by BCL2L1 are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

    Molecular Weight

    26 kDa, 19 kDa

    Gene ID

    598

    NCBI Accession

    NP_612815

    UniProt

    Q07817

    Pathways

    Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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